Maria Paola Martelli Selected Research

Nucleophosmin

12/2021	Novel NPM1 exon 5 mutations and gene fusions leading to aberrant cytoplasmic nucleophosmin in AML.
1/2021	A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML).
1/2021	How I diagnose and treat NPM1-mutated AML.
10/2018	Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates.
5/2015	Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.
11/2011	Acute myeloid leukemia with mutated nucleophosmin (NPM1): any hope for a targeted therapy?
1/2011	Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?
11/2010	CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice.
11/2009	Acute myeloid leukemia with mutated NPM1: diagnosis, prognosis and therapeutic perspectives.
2/2009	Cytoplasmic nucleophosmin is not detected in blastic plasmacytoid dendritic cell neoplasm.

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Maria Paola Martelli Research Topics

Disease

28	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 07/2022 - 05/2005
11	Leukemia 01/2021 - 05/2005
9	Neoplasms (Cancer) 01/2017 - 09/2006
5	Residual Neoplasm 01/2019 - 04/2007
4	Lymphoma (Lymphomas) 12/2019 - 04/2007
2	Infections 07/2022 - 10/2014
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 05/2005
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2009 - 02/2009
2	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 07/2009 - 04/2007
1	Philadelphia Chromosome 01/2022
1	Asthenia 01/2022
1	Erythema 01/2022
1	Exanthema (Rash) 01/2022
1	Fatigue 05/2021
1	Chronic Disease (Chronic Diseases) 05/2021
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/2019
1	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 09/2019
1	B-Cell Lymphoma (Lymphoma, B Cell) 09/2019
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 09/2019
1	Aneurysm (Aneurysms) 09/2019
1	Acute Promyelocytic Leukemia 05/2015
1	Hairy Cell Leukemia 02/2015
1	Genomic Instability 11/2014
1	Melanoma (Melanoma, Malignant) 04/2013
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2011
1	Mitochondrial Diseases (Mitochondrial Disease) 11/2008
1	Hematologic Neoplasms (Hematological Malignancy) 04/2007
1	Graft vs Host Disease (Graft-Versus-Host Disease) 05/2005

Drug/Important Bio-Agent (IBA)

18	NucleophosminIBA 12/2021 - 06/2006
7	Biological ProductsIBA 01/2021 - 04/2007
3	Nuclear Export Signals (Nuclear Export Signal)IBA 12/2021 - 07/2007
3	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2007
2	Oxidoreductases (Dehydrogenase)IBA 01/2021 - 11/2008
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2016 - 05/2015
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 09/2009 - 02/2009
1	Alanine Transaminase (SGPT)IBA 01/2022
1	ponatinibIBA 01/2022
1	SteroidsIBA 01/2022
1	Tyrosine Kinase InhibitorsIBA 01/2022
1	Tryptophan (L-Tryptophan)FDA Link 12/2021
1	Protein CIBA 12/2021
1	isocitric acid (isocitrate)IBA 01/2021
1	Protein Isoforms (Isoforms)IBA 01/2021
1	EnzymesIBA 10/2020
1	Agammaglobulinaemia Tyrosine KinaseIBA 12/2019
1	ibrutinibIBA 12/2019
1	Immune Checkpoint InhibitorsIBA 12/2019
1	FibrinIBA 09/2019
1	Peptides (Polypeptides)IBA 01/2019
1	Staphylococcal Protein A (Protein A)IBA 01/2019
1	AntigensIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 10/2017
1	Long Noncoding RNAIBA 10/2017
1	Complement System Proteins (Complement)IBA 01/2017
1	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2016
1	Dactinomycin (Actinomycin)FDA LinkGeneric 09/2015
1	Arsenic Trioxide (Trisenox)FDA Link 05/2015
1	Retinoic Acid Receptors (Retinoic Acid Receptor)IBA 05/2015
1	Oncogene Proteins (Oncogene Protein)IBA 05/2015
1	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 11/2014
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 04/2013
1	Monoclonal AntibodiesIBA 11/2012
1	Immunoglobulins (Immunoglobulin)IBA 11/2012
1	Co-Repressor ProteinsIBA 01/2012
1	CCAAT-Enhancer-Binding Protein-deltaIBA 08/2011
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 08/2011
1	Fatty Acids (Saturated Fatty Acids)IBA 08/2011
1	Docosahexaenoic AcidsIBA 08/2011
1	Eicosapentaenoic AcidIBA 08/2011
1	Phosphotransferases (Kinase)IBA 02/2009
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2008
1	NAD (NADH)IBA 11/2008
1	Nuclear Proteins (Protein, Nuclear)IBA 05/2008
1	NucleotidesIBA 03/2008
1	MicroRNAs (MicroRNA)IBA 03/2008
1	AntibodiesIBA 04/2007
1	Anaplastic Lymphoma KinaseIBA 04/2007
1	ParaffinIBA 09/2006
1	fludarabineIBA 05/2005
1	Antilymphocyte Serum (Anti-Thymocyte Globulin)IBA 05/2005
1	Thiotepa (Triethylenethiophosphoramide)FDA LinkGeneric 05/2005

Therapy/Procedure

8	Therapeutics 07/2022 - 07/2009
2	Drug Therapy (Chemotherapy) 07/2022 - 12/2016
2	Hematopoietic Stem Cell Transplantation 01/2021 - 05/2005
1	Immunotherapy 01/2019
1	Salvage Therapy 01/2019
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/2014
1	Molecular Targeted Therapy 05/2008
1	Transplantation 05/2005